Glucose sensing in biotissue phantom by spatial resolved reflectometry: Monte Carlo simulations

Mikhail Yu. Kirillin; Alexander V. Bykov; Alexander V. Priezzhev; Risto Myllyla

doi:10.1117/12.741513

1 May 2007 Glucose sensing in biotissue phantom by spatial resolved reflectometry: Monte Carlo simulations

Mikhail Yu. Kirillin, Alexander V. Bykov, Alexander V. Priezzhev, Risto Myllyla

Proceedings Volume 6534, Fifth International Conference on Photonics and Imaging in Biology and Medicine; 65343A (2007) https://doi.org/10.1117/12.741513
Event: Fifth International Conference on Photonics and Imaging in Biology and Medicine, 2006, Wuhan, China

Abstract

The possibility of spatial resolved reflectometry (SRR) application at wavelength of 820 nm for the detection of changes in optical properties of multilayer scattering medium was considered. The considered changes correspond to changes induced by glucose level variations in model biotissue. The model signals from a 3-layer biotissue phantom mimicking two skin layers and a blood layer between them were obtained by implementing Monte Carlo technique. It was supposed that changes in the glucose level induce changes in the blood layer and the deeper skin layer. In order to analyze the trajectories of the photons contributing to the signal, the scattering maps were obtained. Relative changes of the signal induced by the glucose level variations was analyzed for different source-detector separations. It was shown that the maximal relative change of the signal of about 7% corresponding to the glucose concentration change from 0 to 500 mg/dl takes place for source-detector separations in the range from 0.3 to 0.5 mm depending on the model parameters.

Citation Download Citation

Mikhail Yu. Kirillin, Alexander V. Bykov, Alexander V. Priezzhev, and Risto Myllyla "Glucose sensing in biotissue phantom by spatial resolved reflectometry: Monte Carlo simulations", Proc. SPIE 6534, Fifth International Conference on Photonics and Imaging in Biology and Medicine, 65343A (1 May 2007); https://doi.org/10.1117/12.741513

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