Positive changes in the myocardium of SHR rats induced by photon radiation

I. M. Santalova; N. M. Zakharova; R. N. Khramov; I. V. Kraev; A. N. Murashev; A. S. Averin; L. Frachranurova

doi:10.1117/12.781306

2 May 2008 Positive changes in the myocardium of SHR rats induced by photon radiation

I. M. Santalova, N. M. Zakharova, R. N. Khramov, I. V. Kraev, A. N. Murashev, A. S. Averin, L. Frachranurova

Proceedings Volume 6991, Biophotonics: Photonic Solutions for Better Health Care; 699125 (2008) https://doi.org/10.1117/12.781306
Event: SPIE Photonics Europe, 2008, Strasbourg, France

Abstract

Hypertensive SHR male rats were irradiated by a photon light-emitting diode matrix with a maximum irradiation at 612 nm with dose 1.44 J/cm² per day . After a course of irradiation (13 days) the rhythmoinothropic characteristics of cardiac muscle significantly improved. Morphological analysis shown considerable changes in the structure of sarcoplasmic reticulum (SR), i.e. area of SR profiles increased more than twofold compared to control. This suggests a proportional increase in ability of SR to absorb calcium, due to both an increase in its buffer capacity and possibly, an improved functioning of Ca²⁺ ATPase of the reticulum. This could lead to an improvement in calcium homeostasis in the myocytes, and explain the improvement of the characteristics of cardiac muscle contraction-relaxation cycle. Furthermore, changes were observed in proportions of the myocardium capillaries (increased by 75%; compared to control, p<0.001) and in the area of mitochondrial profiles of the myocytes (increased by 13%, p<0.05). This lead to of more active metabolic processes and an energy rise occurring in myocardial cells after photon radiation treatment.

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I. M. Santalova, N. M. Zakharova, R. N. Khramov, I. V. Kraev, A. N. Murashev, A. S. Averin, and L. Frachranurova "Positive changes in the myocardium of SHR rats induced by photon radiation", Proc. SPIE 6991, Biophotonics: Photonic Solutions for Better Health Care, 699125 (2 May 2008); https://doi.org/10.1117/12.781306

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