Advances in the visualization of unstained brain tumors using grating-based x-ray phase-contrast tomography

Franz Pfeiffer; Oliver Bunk; Christian David; Martin Bech; Geraldine Le Duc; Alberto Bravin; Peter Cloetens

doi:10.1117/12.794666

16 September 2008 Advances in the visualization of unstained brain tumors using grating-based x-ray phase-contrast tomography

Franz Pfeiffer, Oliver Bunk, Christian David, Martin Bech, Geraldine Le Duc, Alberto Bravin, Peter Cloetens

Author Affiliations +

Proceedings Volume 7078, Developments in X-Ray Tomography VI; 707815 (2008) https://doi.org/10.1117/12.794666
Event: Optical Engineering + Applications, 2008, San Diego, California, United States

Abstract

We report advances and complementary results concerning a recently developed method for high-sensitivity grating-based hard x-ray phase tomography. We demonstrate how the soft tissue sensitivity of the technique can be used to obtain in-vitro tomographic images of a tumor bearing rat brain specimen, without use of contrast agents. In particular, we demonstrate that brain tumors and the white and gray brain matter structure in a rat's cerebellum can be resolved by this approach. The findings are potentially interesting from a clinical point of view, since a similar approach using three transmission gratings can be implemented with more readily available x-ray sources, such as standard x-ray tubes. Moreover, open the results the way to in-vivo experiments in the near future.

Citation Download Citation

Franz Pfeiffer, Oliver Bunk, Christian David, Martin Bech, Geraldine Le Duc, Alberto Bravin, and Peter Cloetens "Advances in the visualization of unstained brain tumors using grating-based x-ray phase-contrast tomography", Proc. SPIE 7078, Developments in X-Ray Tomography VI, 707815 (16 September 2008); https://doi.org/10.1117/12.794666

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