Revealing fine microstructural morphology in the living human retina using Optical Coherence Tomography with pancorrection

C. Torti; B. Považay; B. Hofer; A. Unterhuber; B. Hermann; W. Drexler

doi:10.1117/12.820631

30 December 2008 Revealing fine microstructural morphology in the living human retina using Optical Coherence Tomography with pancorrection

C. Torti, B. Považay, B. Hofer, A. Unterhuber, B. Hermann, W. Drexler

Author Affiliations +

Proceedings Volume 7139, 1st Canterbury Workshop on Optical Coherence Tomography and Adaptive Optics; 71390Q (2008) https://doi.org/10.1117/12.820631
Event: 1st Canterbury Workshop and School in Optical Coherence Tomography and Adaptive Optics, 2008, Canterbury, United Kingdom

Abstract

Ultra-high speed optical coherence tomography employing an ultra-broadband light source has been combined with adaptive optics utilizing a single high stroke deformable mirror and chromatic aberration compensation. The reduction of motion artefacts, geometric and chromatic aberrations (pancorrection) permits to achieve an isotropic resolution of 2-3 μm in the human eye. The performance of this non-invasive imaging modality enables to resolve cellular structures including cone photoreceptors, nerve fibre bundles and collagenous plates of the lamina cribrosa, and retinal pigment epithelial (RPE) cells in the human retina in vivo with superior detail. Alterations of cellular morphology due to cone degeneration in a colour-blind subject are investigated in ultra-high resolution with selective depth sectioning for the first time.

Citation Download Citation

C. Torti, B. Považay, B. Hofer, A. Unterhuber, B. Hermann, and W. Drexler "Revealing fine microstructural morphology in the living human retina using Optical Coherence Tomography with pancorrection", Proc. SPIE 7139, 1st Canterbury Workshop on Optical Coherence Tomography and Adaptive Optics, 71390Q (30 December 2008); https://doi.org/10.1117/12.820631

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