Design and realization of label-free optical immunosensor based on porous silicon microcavities

Xiao-yi Lü; Tao Xue; Zhen-hong Jia; Hua-wei Shao; Shi-bin Hou; Fu-chun Zhang

doi:10.1117/12.811386

2 February 2009 Design and realization of label-free optical immunosensor based on porous silicon microcavities

Xiao-yi Lü, Tao Xue, Zhen-hong Jia, Hua-wei Shao, Shi-bin Hou, Fu-chun Zhang

Proceedings Volume 7157, 2008 International Conference on Optical Instruments and Technology: Advanced Sensor Technologies and Applications; 71571E (2009) https://doi.org/10.1117/12.811386
Event: International Conference of Optical Instrument and Technology, 2008, Beijing, China

Abstract

We report the experimental demonstration of a novel label-free optical immunosensor based on porous silicon microcavity for the detection of Hydroxysafflor yellow A (HYSA). HYSA antibodies were immobilized into the porous silicon using standard amino-silane and glutaraldehyde chemistry. We monitor the shift of the resonance dip in the reflectance spectrum when HYSA-BSA is attached to the porous silicon microcavity. The label-free immunosensor is simple and exhibit excellent sensitivity for HYSA antibodies with a sensitivity of 0.91nm/ng.

Citation Download Citation

Xiao-yi Lü, Tao Xue, Zhen-hong Jia, Hua-wei Shao, Shi-bin Hou, and Fu-chun Zhang "Design and realization of label-free optical immunosensor based on porous silicon microcavities", Proc. SPIE 7157, 2008 International Conference on Optical Instruments and Technology: Advanced Sensor Technologies and Applications, 71571E (2 February 2009); https://doi.org/10.1117/12.811386

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