X-ray tube-based diffraction enhanced imaging prototype images of full-thickness breast specimens: reader study evaluation

L. S. Faulconer; C. Parham; D. J. Connor; M. Koomen; C. Kuzmiak; D. Pavic; C. A. Livasy; E. Kim; D. Zeng; E. B. Cole; Z. Zhong; E. D. Pisano

doi:10.1117/12.813669

13 March 2009 X-ray tube-based diffraction enhanced imaging prototype images of full-thickness breast specimens: reader study evaluation

L. S. Faulconer, C. Parham, D. J. Connor, M. Koomen, C. Kuzmiak, D. Pavic, C. A. Livasy, E. Kim, D. Zeng, E. B. Cole, Z. Zhong, E. D. Pisano

Author Affiliations +

Proceedings Volume 7258, Medical Imaging 2009: Physics of Medical Imaging; 72585M (2009) https://doi.org/10.1117/12.813669
Event: SPIE Medical Imaging, 2009, Lake Buena Vista (Orlando Area), Florida, United States

Abstract

Conventional mammographic image contrast is derived from x-ray absorption, resulting in breast structure visualization due to density gradients that attenuate radiation without distinction between transmitted and scattered or refracted x-rays. This leads to image blurring and contrast reduction, hindering the early detection of small or otherwise occult cancers. Diffraction enhanced imaging (DEI) allows for dramatically increased contrast with decreased radiation dose compared to conventional mammographic imaging due to monochromatic x-rays, its unique refraction-based contrast mechanism and excellent scatter rejection. However, a lingering drawback to the clinical translation of DEI has been the requirement for synchrotron radiation. Our laboratory developed a DEI prototype (DEI-PR) utilizing a readily available Tungsten xray tube source and traditional DEI crystal optics, providing soft tissue images at 60keV. To demonstrate the clinical utility of our DEI-PR, we acquired images of full-thickness human breast tissue specimens on synchrotron-based DEI, DEI-PR and digital mammography systems. A reader study was designed to allow unbiased assessment of system performance when analyzing three systems with dissimilar imaging parameters and requiring analysis of images unfamiliar to radiologists. A panel of expert radiologists evaluated lesion feature visibility and histopathology correlation after receiving training on the interpretation of refraction contrast mammographic images. Preliminary data analysis suggests that our DEI system performed roughly equivalently with the traditional DEI system, demonstrating a significant step toward clinical translation of this modality for breast cancer applications.

Citation Download Citation

L. S. Faulconer, C. Parham, D. J. Connor, M. Koomen, C. Kuzmiak, D. Pavic, C. A. Livasy, E. Kim, D. Zeng, E. B. Cole, Z. Zhong, and E. D. Pisano "X-ray tube-based diffraction enhanced imaging prototype images of full-thickness breast specimens: reader study evaluation", Proc. SPIE 7258, Medical Imaging 2009: Physics of Medical Imaging, 72585M (13 March 2009); https://doi.org/10.1117/12.813669

ACCESS THE FULL ARTICLE

INSTITUTIONAL
Select your institution to access the SPIE Digital Library.

SELECT YOUR INSTITUTION

PERSONAL
Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.

PERSONAL SIGN IN

No SPIE Account? Create one

PURCHASE THIS CONTENT

SUBSCRIBE TO DIGITAL LIBRARY

50 downloads per 1-year subscription

Members: $195

Non-members: $335 ADD TO CART

25 downloads per 1 - year subscription

Members: $145

Non-members: $250 ADD TO CART

PURCHASE SINGLE ARTICLE

Includes PDF, HTML & Video, when available

Members: $17.00

Non-members: $21.00 ADD TO CART

PROCEEDINGS
10 PAGES

DOWNLOAD PAPER SAVE TO MY LIBRARY

GET CITATION

RIGHTS & PERMISSIONS

Get copyright permission Get copyright permission on Copyright Marketplace

KEYWORDS

X-rays

Imaging systems

Tissues

X-ray imaging

Breast

Refraction

Reflectivity

Show All Keywords

Keywords/Phrases

Search In:

Publication Years