Optimization of a multi-well array SERS chip

J. L. Abell; J. D. Driskell; R. A. Dluhy; R. A. Tripp; Y.-P. Zhao

doi:10.1117/12.820358

4 May 2009 Optimization of a multi-well array SERS chip

J. L. Abell, J. D. Driskell, R. A. Dluhy, R. A. Tripp, Y.-P. Zhao

Proceedings Volume 7321, Bio-Inspired/Biomimetic Sensor Technologies and Applications; 732103 (2009) https://doi.org/10.1117/12.820358
Event: SPIE Defense, Security, and Sensing, 2009, Orlando, Florida, United States

Abstract

SERS-active substrates are fabricated by oblique angle deposition and patterned by a polymer-molding technique to provide a uniform array for high throughput biosensing and multiplexing. Using a conventional SERS-active molecule, 1,2-Bis(4-pyridyl)ethylene (BPE), we show that this device provides a uniform Raman signal enhancement from well to well. The patterning technique employed in this study demonstrates a flexibility allowing for patterning control and customization, and performance optimization of the substrate. Avian influenza is analyzed to demonstrate the ability of this multi-well patterned SERS substrate for biosensing.

Citation Download Citation

J. L. Abell, J. D. Driskell, R. A. Dluhy, R. A. Tripp, and Y.-P. Zhao "Optimization of a multi-well array SERS chip", Proc. SPIE 7321, Bio-Inspired/Biomimetic Sensor Technologies and Applications, 732103 (4 May 2009); https://doi.org/10.1117/12.820358

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