Transverse mode analysis of optofluidic intracavity spectroscopy of canine hemangiosarcoma

Weina Wang; Douglas H. Thamm; David W. Kisker; Kevin L. Lear

doi:10.1117/12.842142

24 February 2010 Transverse mode analysis of optofluidic intracavity spectroscopy of canine hemangiosarcoma

Weina Wang, Douglas H. Thamm, David W. Kisker, Kevin L. Lear

Proceedings Volume 7559, Optical Fibers and Sensors for Medical Diagnostics and Treatment Applications X; 75590C (2010) https://doi.org/10.1117/12.842142
Event: SPIE BiOS, 2010, San Francisco, California, United States

Abstract

The label-free technique of optofluidic intracavity spectroscopy (OFIS) uses the optical transmission spectrum of a cell in a microfluidic optical resonator to distinguish cancerous and non-cancerous cells. Based on their distinctive characteristic transmission spectra, canine hemangiosarcoma (HSA) cancer cells and normal peripheral blood mononuclear cells (PBMCs) have been differentiated using the OFIS technique with high statistical significance (p<10^-
6). 95% sensitivity and 98% specificity were achieved simultaneously. A cell lens model explains trends in the transverse mode pattern in the transmission spectra of HSA cells and allows extraction of cell focal length.

Citation Download Citation

Weina Wang, Douglas H. Thamm, David W. Kisker, and Kevin L. Lear "Transverse mode analysis of optofluidic intracavity spectroscopy of canine hemangiosarcoma", Proc. SPIE 7559, Optical Fibers and Sensors for Medical Diagnostics and Treatment Applications X, 75590C (24 February 2010); https://doi.org/10.1117/12.842142

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