A new image-based process for quantifying hemodynamic contributions to long-term morbidity in a rabbit model of aortic coarctation

David C. Wendell; Ronak J. Dholakia; Paul M. Larsen; Arjun Menon; John F. LaDisa Jr.

doi:10.1117/12.846373

9 March 2010 A new image-based process for quantifying hemodynamic contributions to long-term morbidity in a rabbit model of aortic coarctation

David C. Wendell, Ronak J. Dholakia, Paul M. Larsen, Arjun Menon, John F. LaDisa Jr.

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Proceedings Volume 7626, Medical Imaging 2010: Biomedical Applications in Molecular, Structural, and Functional Imaging; 76260J (2010) https://doi.org/10.1117/12.846373
Event: SPIE Medical Imaging, 2010, San Diego, California, United States

Abstract

Coarctation of the aorta (CoA) is associated with reduced life expectancy despite successful surgical treatment. Interestingly, much of the related long-term morbidity can be explained by abnormal hemodynamics, vascular biomechanics and cardiac function. MRI has played an important role in assessing coarctation severity, but the heterogeneity and small number of patients at each center presents an obstacle for determining causality. This work describes optimized imaging parameters to create computational fluid dynamics (CFD) models revealing changes in hemodynamics and vascular biomechanics from a rabbit model. CoA was induced surgically at 10 weeks using silk or dissolvable ligatures to replicate native and end-to-end treatment cases, respectively. Cardiac function was evaluated at 32 weeks using a fastcard SPGR sequence in 6-8 two-chamber short-axis views. Left ventricular (LV) volume, ejection fraction, and mass were quantified and compared to control rabbits. Phase contrast (PC) and angiographic MRI were used to create CFD models. Ascending aortic PCMRI data were mapped to the model inflow and outflow boundary conditions replicated measured pressure (BP) and flow. CFD simulations were performed using a stabilized finite element method to calculate indices including velocity, BP and wall shear stress (WSS). CoA models displayed higher velocity through the coarctation region and decreased velocity elsewhere, leading to decreased WSS above and below the stenosis. Pronounced wall displacement was associated with CoA-induced changes in BP. CoA caused reversible LV hypertrophy. Cardiac function was maintained, but caused a persistent hyperdynamic state. This model may now be used to investigate potential mechanisms of long-term morbidity.

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David C. Wendell, Ronak J. Dholakia, Paul M. Larsen, Arjun Menon, and John F. LaDisa Jr. "A new image-based process for quantifying hemodynamic contributions to long-term morbidity in a rabbit model of aortic coarctation", Proc. SPIE 7626, Medical Imaging 2010: Biomedical Applications in Molecular, Structural, and Functional Imaging, 76260J (9 March 2010); https://doi.org/10.1117/12.846373

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KEYWORDS

Hemodynamics

Data modeling

Arteries

Magnetic resonance imaging

Blood circulation

Blood pressure

Heart

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