High performance multichannel photonic biochip sensors for future point of care diagnostics: an overview on two EU-sponsored projects

Domenico Giannone; Andrzej Kazmierczak; Fabian Dortu; Laurent Vivien; Hans Sohlström

doi:10.1117/12.854197

17 May 2010 High performance multichannel photonic biochip sensors for future point of care diagnostics: an overview on two EU-sponsored projects

Domenico Giannone, Andrzej Kazmierczak, Fabian Dortu, Laurent Vivien, Hans Sohlström

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Proceedings Volume 7715, Biophotonics: Photonic Solutions for Better Health Care II; 77150U (2010) https://doi.org/10.1117/12.854197
Event: SPIE Photonics Europe, 2010, Brussels, Belgium

Abstract

We present here research work on two optical biosensors which have been developed within two separate European projects (6th and 7th EU Framework Programmes). The biosensors are based on the idea of a disposable biochip, integrating photonics and microfluidics, optically interrogated by a multichannel interrogation platform. The objective is to develop versatile tools, suitable for performing screening tests at Point of Care or for example, at schools or in the field. The two projects explore different options in terms of optical design and different materials. While SABIO used Si₃N₄/SiO₂ ring resonators structures, P3SENS aims at the use of photonic crystal devices based on polymers, potentially a much more economical option. We discuss both approaches to show how they enable high sensitivity and multiple channel detection. The medium term objective is to develop a new detection system that has low cost and is portable but at the same time offering high sensitivity, selectivity and multiparametric detection from a sample containing various components (e.g. blood, serum, saliva, etc.). Most biological sensing devices already present on the market suffer from limitations in multichannel operation capability (either the detection of multiple analytes indicating a given pathology or the simultaneous detection of multiple pathologies). In other words, the number of different analytes that can be detected on a single chip is very limited. This limitation is a main issue addressed by the two projects. The excessive cost per test of conventional bio sensing devices is a second issue that is addressed.

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Domenico Giannone, Andrzej Kazmierczak, Fabian Dortu, Laurent Vivien, and Hans Sohlström "High performance multichannel photonic biochip sensors for future point of care diagnostics: an overview on two EU-sponsored projects", Proc. SPIE 7715, Biophotonics: Photonic Solutions for Better Health Care II, 77150U (17 May 2010); https://doi.org/10.1117/12.854197

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KEYWORDS

Sensors

Integrated optics

Waveguides

Refractive index

Optical alignment

Silicon

Proteins

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