Molecular-level engineering of THz/IR-sensitive materials for future biological sensing application

Dwight Woolard; Gregory Recine; Alexei Bykhovski; Weidong Zhang

doi:10.1117/12.865580

9 September 2010 Molecular-level engineering of THz/IR-sensitive materials for future biological sensing application

Dwight Woolard, Gregory Recine, Alexei Bykhovski, Weidong Zhang

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Proceedings Volume 7763, Terahertz Emitters, Receivers, and Applications; 77630D (2010) https://doi.org/10.1117/12.865580
Event: SPIE NanoScience + Engineering, 2010, San Diego, California, United States

Abstract

While the unique spectral information associated with chemical and biological molecules within the terahertz frequency regime (~ 3.0-3.0 millimeters) motivates its use for practical sensing applications, limiting factors at the macroscale (weak spectral absorption, broad line widths and masking geometrical effects introduced by the samples) provides motivation for man-engineered sensing materials that allow for the transduction of the spectral information about target molecules from the nanoscale. This brief letter will overview work being performed by our research group to define molecular-level functionality that will be useful for realizing "THz/IR-sensitive" materials. Here the goal is to define switchable molecular components that when incorporated into larger DNA-based nanoscaffolds lead to THz and/or IR regime electronic and/or photonic material properties that are dictated in a predictable manner by novel functionality paradigms. In particular, theoretical modeling and design studies are being performed to engineer organic and biological switches that can be incorporated into DNA-based architectures that enable the precise extraction of nanoscale information (e.g., composition, dynamics, conformation) through electronic/photonic transformations to the macroscale. Hence, these studies seek to define new spectral-based sensing modalities useful for characterizing bio-molecules

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Dwight Woolard, Gregory Recine, Alexei Bykhovski, and Weidong Zhang "Molecular-level engineering of THz/IR-sensitive materials for future biological sensing application", Proc. SPIE 7763, Terahertz Emitters, Receivers, and Applications, 77630D (9 September 2010); https://doi.org/10.1117/12.865580

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KEYWORDS

Molecules

Biosensing

Switches

Dielectrics

Molecular biology

Absorption

Terahertz radiation

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