Real-time intraoperative full-range complex FD-OCT guided cerebral blood vessel identification and brain tumor resection in neurosurgery

Kang Zhang; Yong Huang; Gustavo Pradilla; Betty Tyler; Jin U. Kang

doi:10.1117/12.874190

18 February 2011 Real-time intraoperative full-range complex FD-OCT guided cerebral blood vessel identification and brain tumor resection in neurosurgery

Kang Zhang, Yong Huang, Gustavo Pradilla, Betty Tyler, Jin U. Kang

Author Affiliations +

Proceedings Volume 7883, Photonic Therapeutics and Diagnostics VII; 78833Y (2011) https://doi.org/10.1117/12.874190
Event: SPIE BiOS, 2011, San Francisco, California, United States

Abstract

This work utilized an ultra-high-speed full-range complex-conjugate-free optical coherence tomography (FD-OCT) system to perform real-time intraoperative imaging to guide two common neurosurgical procedures: the cerebral blood vessel identification and the brain tumor resection. The cerebral blood vessel identification experiment is conducted ex vivo on human cadaver specimen. Specific cerebral arteries and veins in different positions of the specimen are visualized and the spatial relations between adjacent vessels are indentified through real-time 3D visualization. The brain tumor resection experiment is conducted in vivo on 9L gliomas established in rat brains. The normal brain-tumor margin can be clearly identified in depth of the tissue from sagittal, coronal and axial slices of the intraoperatively acquired 3D data set. The real-time full-range FD-OCT guided in vivo rat flank tumor resection is also conducted.

Citation Download Citation

Kang Zhang, Yong Huang, Gustavo Pradilla, Betty Tyler, and Jin U. Kang "Real-time intraoperative full-range complex FD-OCT guided cerebral blood vessel identification and brain tumor resection in neurosurgery", Proc. SPIE 7883, Photonic Therapeutics and Diagnostics VII, 78833Y (18 February 2011); https://doi.org/10.1117/12.874190

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