Cortical blood flow imaging of mouse stroke model by high-speed Spectral OCT

Ireneusz Grulkowski; Grzegorz Wilczynski; Danuta Bukowska; Maciej Szkulmowski; Jakub Wlodarczyk; Karol Karnowski; Daniel Ruminski; Andrzej Kowalczyk; Maciej Wojtkowski

doi:10.1117/12.875212

23 March 2011 Cortical blood flow imaging of mouse stroke model by high-speed Spectral OCT

Ireneusz Grulkowski, Grzegorz Wilczynski, Danuta Bukowska, Maciej Szkulmowski, Jakub Wlodarczyk, Karol Karnowski, Daniel Ruminski, Andrzej Kowalczyk, Maciej Wojtkowski

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Proceedings Volume 7883, Photonic Therapeutics and Diagnostics VII; 788342 (2011) https://doi.org/10.1117/12.875212
Event: SPIE BiOS, 2011, San Francisco, California, United States

Abstract

We have developed and applied a high-speed Spectral OCT system to image small animal brains. OCT imaging with high spatial resolution and application of multi-parameter approach enabled cortical blood flow visualization. We imaged the brain vascular network of an anesthetized mouse stroke model. We demonstrated the impact of induced stroke on the brain vasculature. The preliminary studies have revealed local ischemia in the areas of the stroke.

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Ireneusz Grulkowski, Grzegorz Wilczynski, Danuta Bukowska, Maciej Szkulmowski, Jakub Wlodarczyk, Karol Karnowski, Daniel Ruminski, Andrzej Kowalczyk, and Maciej Wojtkowski "Cortical blood flow imaging of mouse stroke model by high-speed Spectral OCT", Proc. SPIE 7883, Photonic Therapeutics and Diagnostics VII, 788342 (23 March 2011); https://doi.org/10.1117/12.875212

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KEYWORDS

Optical coherence tomography

Brain

Blood circulation

Doppler effect

Visualization

Neuroimaging

Scanners

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