Concurrent magnetic resonance and diffuse luminescence imaging for hypoxic tumor characterization

Madhavi Seetamraju; Xuefeng Zhang; Scott Davis; Rajan Gurjar; Richard Myers; Brian W. Pogue; Gerald Entine

doi:10.1117/12.875554

10 February 2011 Concurrent magnetic resonance and diffuse luminescence imaging for hypoxic tumor characterization

Madhavi Seetamraju, Xuefeng Zhang, Scott Davis, Rajan Gurjar, Richard Myers, Brian W. Pogue, Gerald Entine

Proceedings Volume 7892, Multimodal Biomedical Imaging VI; 78920K (2011) https://doi.org/10.1117/12.875554
Event: SPIE BiOS, 2011, San Francisco, California, United States

Abstract

In this paper we present the details of a Diffuse Optical Tomographic (DOT) prototype instrument developed and characterized at RMD for concurrent operation with Magnetic Resonance Imaging (MRI) to obtain high resolution spatial and functional images of hypoxic tumor tissue. We have developed a new system designed for in-vivo imaging of luminescent agents that respond to tissue oxygenation to improve the contrast and spatial resolution of functional optical images in deep tissue. High-resolution spatial and anatomical information obtained from MRI images is used to improve the accuracy of the reconstructed optical images. The time domain lifetime imaging module has parallel acquisition across a cooled 16-element avalanche photodiode (APD) array for high resolution and high throughput imaging. The low-cost, compact lifetime imager is compatible with high magnetic and RF fields associated with MR units in hybrid imaging systems. Using this APD module in a dual-modality imaging setup, phantom imaging was performed to obtain oxygenation images with high resolution and contrast. Optical image reconstruction is aided by spatial guidance obtained from the actual phantom dimensions to improve the accuracy of these images.

Citation Download Citation

Madhavi Seetamraju, Xuefeng Zhang, Scott Davis, Rajan Gurjar, Richard Myers, Brian W. Pogue, and Gerald Entine "Concurrent magnetic resonance and diffuse luminescence imaging for hypoxic tumor characterization", Proc. SPIE 7892, Multimodal Biomedical Imaging VI, 78920K (10 February 2011); https://doi.org/10.1117/12.875554

ACCESS THE FULL ARTICLE

INSTITUTIONAL
Select your institution to access the SPIE Digital Library.

SELECT YOUR INSTITUTION

PERSONAL
Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.

PERSONAL SIGN IN

No SPIE Account? Create one

PURCHASE THIS CONTENT

SUBSCRIBE TO DIGITAL LIBRARY

50 downloads per 1-year subscription

Members: $195

Non-members: $335 ADD TO CART

25 downloads per 1 - year subscription

Members: $145

Non-members: $250 ADD TO CART

PURCHASE SINGLE ARTICLE

Includes PDF, HTML & Video, when available