Fluorescence-enhanced optical tomography using phase information

Yujie Lu; Eva M. Sevick-Muraca

doi:10.1117/12.873589

17 February 2011 Fluorescence-enhanced optical tomography using phase information

Yujie Lu, Eva M. Sevick-Muraca

Proceedings Volume 7896, Optical Tomography and Spectroscopy of Tissue IX; 78960K (2011) https://doi.org/10.1117/12.873589
Event: SPIE BiOS, 2011, San Francisco, California, United States

Abstract

Fluorescence-enhanced optical imaging/tomography (FEOI/FEOT) could play an important role in drug discovery and clinical diagnostics. In recent years, improvement in spatial resolution and quantitative biological information has been increasingly promised. Time- and frequency-resolved FEOT has great potential to obtain improved reconstruction information compared with continuous wave (CW) mode due to the acquisition of more measurement information. In this paper, a phase-only FEOT(PO-FEOT) is proposed and evaluated. In PO-FEOT, a finite element-based linear relationship between the unknown fluorophore variables and phase information obtained from time- and frequency-domain boundary measurements is used in FEOT reconstruction. Synthetic data shows that, compared to the amplitude and phase-based reconstruction, the reconstruction time cost is remarkably reduced when phase is used alone. The reconstructed results show that PO-FEOT with high frequency information can acquire preferable reconstruction quality.

Citation Download Citation

Yujie Lu and Eva M. Sevick-Muraca "Fluorescence-enhanced optical tomography using phase information", Proc. SPIE 7896, Optical Tomography and Spectroscopy of Tissue IX, 78960K (17 February 2011); https://doi.org/10.1117/12.873589

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