Developing a tool for the validation of quantitative DCE-MRI

Karin Bol; Joost C. Haeck; Lejla Alic; Monique Bernsen; Marion de Jong; Wiro J. Niessen; Jifke F. Veenland

doi:10.1117/12.877834

9 March 2011 Developing a tool for the validation of quantitative DCE-MRI

Karin Bol, Joost C. Haeck, Lejla Alic, Monique Bernsen, Marion de Jong, Wiro J. Niessen, Jifke F. Veenland

Proceedings Volume 7965, Medical Imaging 2011: Biomedical Applications in Molecular, Structural, and Functional Imaging; 79651J (2011) https://doi.org/10.1117/12.877834
Event: SPIE Medical Imaging, 2011, Lake Buena Vista (Orlando), Florida, United States

Abstract

Dynamic Contrast-Enhanced Magnetic Resonance Imaging (DCE-MRI) is becoming an indispensable tool to non-invasively study tumor characteristics. However, many different DCE-analysis methods are currently being used. To compare and validate different methods, histology is the gold standard. For this purpose, exact co-localization between histology and MRI images is a prerequisite. In this study a methodology is developed to validate DCE-data with histology with an emphasis on correct registration of DCE-MRI and histological data. A pancreatic tumor was grown in a rat model. The tumor was dissected after MR imaging, embedded in paraffin, and cut into thin slices. These slices were stained with haematoxylin and eosin, digitized and stacked in a 3D volume. Next, the 3D histology was registered to ex-vivo SWI-weighted MR images, which in turn were registered to in-vivo SWI and DCE images to achieve correct co-localization. Semi-quantitative and quantitative parameters were calculated. Preliminary results suggest that both pharmacokinetic and heuristic DCE-parameters can discriminate between vital and non-vital tumor regions. The developed method offers the basis for an accurate spatial correlation between DCE-MRI derived parametric maps and histology, and facilitates the evaluation of different DCE-MRI analysis methods.

Citation Download Citation

Karin Bol, Joost C. Haeck, Lejla Alic, Monique Bernsen, Marion de Jong, Wiro J. Niessen, and Jifke F. Veenland "Developing a tool for the validation of quantitative DCE-MRI", Proc. SPIE 7965, Medical Imaging 2011: Biomedical Applications in Molecular, Structural, and Functional Imaging, 79651J (9 March 2011); https://doi.org/10.1117/12.877834

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