Model-based spectral analysis of photon propagation through nanoparticle-labeled epithelial tissues

Can Cihan; Dizem Arifler

doi:10.1117/12.889421

15 June 2011 Model-based spectral analysis of photon propagation through nanoparticle-labeled epithelial tissues

Can Cihan, Dizem Arifler

Proceedings Volume 8087, Clinical and Biomedical Spectroscopy and Imaging II; 80872I (2011) https://doi.org/10.1117/12.889421
Event: European Conferences on Biomedical Optics, 2011, Munich, Germany

Abstract

Metal nanoparticles can function as optical contrast enhancers for reflectance-based diagnosis of epithelial precancer. We carry out Monte Carlo simulations to model photon propagation through normal tissues, unlabeled precancerous tissues, and precancerous tissues labeled with gold nanospheres and we compute the spectral reflectance response of these different tissue states. The results indicate that nanoparticle-induced changes in the spectral reflectance profile of tissues depend not only on the properties of these particles but also on the source-detector geometry used. When the source and detector fibers are oriented side by side and perpendicular to the tissue surface, the reflectance intensity of precancerous tissue is lower compared to that of normal tissue over the entire wavelength range simulated and addition of nanospheres enhances this negative contrast. When the fibers are tilted toward each other, the reflectance intensity of precancerous tissue is higher compared to that of normal tissue and labeling with nanospheres causes a significant enhancement of this positive contrast. The results also suggest that model-based spectral analysis of photon propagation through nanoparticle-labeled tissues provides a useful framework to quantify the extent of achievable contrast enhancement due to external labeling and to assess the diagnostic potential of nanoparticle-enhanced optical measurements.

Citation Download Citation

Can Cihan and Dizem Arifler "Model-based spectral analysis of photon propagation through nanoparticle-labeled epithelial tissues", Proc. SPIE 8087, Clinical and Biomedical Spectroscopy and Imaging II, 80872I (15 June 2011); https://doi.org/10.1117/12.889421

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KEYWORDS

Tissues

Optical fibers

Reflectivity

Scattering

Gold

Natural surfaces

Tissue optics

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