What we can learn about hereditary dystonia from HSDI of the glottis

Mette Pedersen; Martin Eeg

doi:10.1117/12.920838

9 February 2012 What we can learn about hereditary dystonia from HSDI of the glottis

Mette Pedersen, Martin Eeg

Proceedings Volume 8207, Photonic Therapeutics and Diagnostics VIII; 82072T (2012) https://doi.org/10.1117/12.920838
Event: SPIE BiOS, 2012, San Francisco, California, United States

Abstract

This study examined efficacy of the innate immune defence via the mannose binding lectin (MBL) in a cohort of 55 dystonic patients prospectively referred to the clinic with laryngeal mucosal complaints, who were placed on local steroids (budesonid inhaler, 400 μg 2 times daily) and antihistamines (fexofenadin 180 mg mostly 3 times daily) with adjuvant lifestyle corrections. Treatment efficacy of the larynx was assessed based on mucosal findings of the vocal folds examined with High speed mucosa studies comprising simultaneous high speed digital imagines (HSDI), kymography, electroglottography (EGG) and voice acoustics combined with a visual score of arytenoids oedema, as these measures are indicative of the magnitude of laryngitis. Lactose and gluten intolerance and immunological analyses of the innate system were made systematically. Results showed that the genetic aspects of immunology did not reveal a role for the innate immune system, represented by the mannose binding lectin (MBL). An unexpected positive effect of the larynx treatment on dystonia symptoms was found evidenced by reduction of dystonic complaints and more normative results of High speed mucosa, and a reduction of oedema of the inter arytenoids region. Symptoms relieve and better quality of life was observed on follow up for the dystonia complaints.

Citation Download Citation

Mette Pedersen and Martin Eeg "What we can learn about hereditary dystonia from HSDI of the glottis", Proc. SPIE 8207, Photonic Therapeutics and Diagnostics VIII, 82072T (9 February 2012); https://doi.org/10.1117/12.920838

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Statistical analysis

Defense and security

Genetics

Acoustics

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