High sensitivity surface enhanced Raman scattering detection of organic molecules and amino acids

A. Kandakkathara; I. Utkin; R. Fedosejevs

doi:10.1117/12.2007352

24 October 2012 High sensitivity surface enhanced Raman scattering detection of organic molecules and amino acids

A. Kandakkathara, I. Utkin, R. Fedosejevs

Proceedings Volume 8412, Photonics North 2012; 84120E (2012) https://doi.org/10.1117/12.2007352
Event: Photonics North 2012, 2012, Montréal, Canada

Abstract

Surface enhanced Raman scattering is a promising technique for high sensitivity analytical applications. However, there are issues which have to be addressed in order to make SERS a reliable technique such as the optimization of conditions for any given analyte, understanding the kinetic processes of binding of the target molecules to the nanostructures and understanding the evolution and coagulation of the nanostructures, in the case of colloidal solutions. The background electrolyte is a very important factor in SERS experiments. Here we report a detailed study of the influence of the addition of different types of electrolytes on the amplitude and kinetics of the SERS signal in silver colloids. Different amino acids and organic dyes were used as test molecules in the concentration range of 10^-8 to 10^-4 M. We found that a new proposed electrolyte containing HCO₃, CO₃, Cl and SO₄ ions provides very high enhancement of Raman signal in organic molecules we studied. The advantages of the composite electrolyte are especially noticeable at low concentration of tryptophan where we observed 10⁸ enhancement of Raman signal, approximately 300 times larger than for the case of commonly used electrolyte sodium chloride.

Citation Download Citation

A. Kandakkathara, I. Utkin, and R. Fedosejevs "High sensitivity surface enhanced Raman scattering detection of organic molecules and amino acids", Proc. SPIE 8412, Photonics North 2012, 84120E (24 October 2012); https://doi.org/10.1117/12.2007352

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