Multifunctional superparamagnetic nanoparticles for enhanced drug transport in cystic fibrosis

Leisha M. Armijo; Yekaterina I. Brandt; Antonio C. Rivera; Nathaniel C. Cook; John B. Plumley; Nathan J. Withers; Michael Kopciuch; Gennady A. Smolyakov; Dale L. Huber; Hugh D. Smyth; Marek Osinski

doi:10.1117/12.943621

24 October 2012 Multifunctional superparamagnetic nanoparticles for enhanced drug transport in cystic fibrosis

Leisha M. Armijo, Yekaterina I. Brandt, Antonio C. Rivera, Nathaniel C. Cook, John B. Plumley, Nathan J. Withers, Michael Kopciuch, Gennady A. Smolyakov, Dale L. Huber, Hugh D. Smyth, Marek Osinski

Author Affiliations +

Proceedings Volume 8548, Nanosystems in Engineering and Medicine; 85480E (2012) https://doi.org/10.1117/12.943621
Event: SPIE Nanosystems in Engineering + Medicine, 2012, Incheon, Korea, Republic of

Abstract

Iron oxide colloidal nanoparticles (ferrofluids) are investigated for application in the treatment of cystic fibrosis lung infections, the leading cause of mortality in cystic fibrosis patients. We investigate the use of iron oxide nanoparticles to increase the effectiveness of administering antibiotics through aerosol inhalation using two mechanisms: directed particle movement in the presence of an inhomogeneous static external magnetic field and magnetic hyperthermia. Magnetic hyperthermia is an effective method for decreasing the viscosity of the mucus and biofilm, thereby enhancing drug, immune cell, and antibody penetration to the affected area. Iron oxide nanoparticles of various sizes and morphologies were synthesized and tested for specific losses (heating power). Nanoparticles in the superparamagnetic to ferromagnetic size range exhibited excellent heating power. Additionally, iron oxide / zinc selenide core/shell nanoparticles were prepared, in order to enable imaging of the iron oxide nanoparticles. We also report on synthesis and characterization of MnSe/ZnSeS alloyed quantum dots.

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Leisha M. Armijo, Yekaterina I. Brandt, Antonio C. Rivera, Nathaniel C. Cook, John B. Plumley, Nathan J. Withers, Michael Kopciuch, Gennady A. Smolyakov, Dale L. Huber, Hugh D. Smyth, and Marek Osinski "Multifunctional superparamagnetic nanoparticles for enhanced drug transport in cystic fibrosis", Proc. SPIE 8548, Nanosystems in Engineering and Medicine, 85480E (24 October 2012); https://doi.org/10.1117/12.943621

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