Laser-driven short-duration heating angioplasty: dilatation performance in cadaver atherosclerotic femoral arteries

Natsumi Shimazaki; Sho Naruse; Tsunenori Arai; Nobuaki Imanishi; Sadakazu Aiso

doi:10.1117/12.2005432

8 March 2013 Laser-driven short-duration heating angioplasty: dilatation performance in cadaver atherosclerotic femoral arteries

Natsumi Shimazaki, Sho Naruse, Tsunenori Arai, Nobuaki Imanishi, Sadakazu Aiso

Author Affiliations +

Proceedings Volume 8565, Photonic Therapeutics and Diagnostics IX; 85654E (2013) https://doi.org/10.1117/12.2005432
Event: SPIE BiOS, 2013, San Francisco, California, United States

Abstract

The purpose of this study was to investigate the artery dilatation performance of the short-duration heating balloon catheter in cadaver stenotic arteries. We designed a prototype short-duration heating balloon catheter that can heat artery media to around 60 °C in 15−25 s by a combination of laser-driven heat generation and continuous fluid irrigation in the balloon. We performed ex vivo short-duration heating dilatation in the cadaver atherosclerotic femoral arteries (initial percent diameter stenosis was 36-98%), with the maximum balloon temperature of 65±5 °C, laser irradiation duration of 25 s, and balloon dilatation pressure of 3.5 atm. The artery lumen configurations before and after the dilatations were assessed with a commercial IVUS system. After the short-duration heating dilatations, the percent diameter stenosis was reduced below 30% without any artery tears or dissections. We estimated that the artery media temperature was raised to around 60 °C in which plaque thickness was below 0.8 mm by a thermal conduction calculation. The estimated maximum temperature in artery adventitia and surrounding tissue was up to 45 °C. We found that the short-duration heating balloon could sufficiently dilate the cadaver stenotic arteries, without thermal injury in artery adventitia and surroundings.

Citation Download Citation

Natsumi Shimazaki, Sho Naruse, Tsunenori Arai, Nobuaki Imanishi, and Sadakazu Aiso "Laser-driven short-duration heating angioplasty: dilatation performance in cadaver atherosclerotic femoral arteries", Proc. SPIE 8565, Photonic Therapeutics and Diagnostics IX, 85654E (8 March 2013); https://doi.org/10.1117/12.2005432

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