Photodynamic characterization and optimization using multifunctional nanoparticles for brain cancer treatment

Kristen Herrmann; Yong-Eun Lee Koo; Daniel A. Orringer; Oren Sagher; Martin Philbert; Raoul Kopelman

doi:10.1117/12.2005530

13 March 2013 Photodynamic characterization and optimization using multifunctional nanoparticles for brain cancer treatment

Kristen Herrmann, Yong-Eun Lee Koo, Daniel A. Orringer, Oren Sagher, Martin Philbert, Raoul Kopelman

Author Affiliations +

Proceedings Volume 8568, Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy XXII; 85680I (2013) https://doi.org/10.1117/12.2005530
Event: SPIE BiOS, 2013, San Francisco, California, United States

Abstract

Photosensitizer-conjugated polyacrylamide nanoparticles were prepared for in vivo characterization of the minimally invasive and localized treatment of photodynamic therapy (PDT) on brain tumors. By incorporating a variety of nanoparticle matrixes, choosing methylene blue as a photosensitizer, and targeting the nanoparticle by the use of F3 peptide we have made nanoparticle-based PDT improvements to current PDT efficiency. Quantitative growth patterns were determined through visual observation of the tumorigenic response to various treatments by the use of an animal cranial window model. PDT treatments with methylene blue-polyacrylamide (MB-PAA) nanoparticles produced significant adjournment of tumor growth over control groups, clearly demonstrating the advantages of nanoparticle-based PDT agents for the eradication of local tumors, leading to the potential palliation of the advancing disease.

Citation Download Citation

Kristen Herrmann, Yong-Eun Lee Koo, Daniel A. Orringer, Oren Sagher, Martin Philbert, and Raoul Kopelman "Photodynamic characterization and optimization using multifunctional nanoparticles for brain cancer treatment", Proc. SPIE 8568, Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy XXII, 85680I (13 March 2013); https://doi.org/10.1117/12.2005530

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