Locally applied simvastatin improves fracture healing at late period in osteoporotic rat

Faming Tian; Liu Zhang; Yuchuan Kang; Junshan Zhang; Jiao Ao; Fang Yang

doi:10.1117/12.2019682

19 March 2013 Locally applied simvastatin improves fracture healing at late period in osteoporotic rat

Faming Tian, Liu Zhang, Yuchuan Kang, Junshan Zhang, Jiao Ao, Fang Yang

Proceedings Volume 8762, PIAGENG 2013: Intelligent Information, Control, and Communication Technology for Agricultural Engineering; 87621S (2013) https://doi.org/10.1117/12.2019682
Event: Third International Conference on Photonics and Image in Agriculture Engineering (PIAGENG 2013), 2013, Sanya, China

Abstract

effect of simvastatin locally applied from a bioactive polymer coating of implants on osteoporotic fracture healing at late period. Methods:Femur fracture model was established on normal or osteotoporotic mature female SD rats, intramedullary stabilization was achieved with uncoated titanium Kirschnerwires in normal rats(group A),with polymer-only coated vs. polymer plus simvastatin coated titanium Kirschner wires in osteoporotic rats(group B and C, respectively).Femurs were harvested after 12 weeks, and underwent radiographic and histologic analysis, as well as immunohistochemical evaluation for BMP-2 expression. Results:Radiographic results demonstrated progressed callus in the simvastatin-treated groups compared to the uncoated group.The histologic analysis revealed a significantly processed callus with irregular-shaped newly formed bone trabeculae in simvastatin-treated group. Immunohistochemical evaluation showed markedly higher expression levels of B:MP-2 in simvastatin-treated group.Conclusions: The present study revealed a improved fracture healing under local application of simvastatin in osteoporotic rat,which might partially from upregulation of the B:MP-2 expression at fractured site.

Citation Download Citation

Faming Tian, Liu Zhang, Yuchuan Kang, Junshan Zhang, Jiao Ao, and Fang Yang "Locally applied simvastatin improves fracture healing at late period in osteoporotic rat", Proc. SPIE 8762, PIAGENG 2013: Intelligent Information, Control, and Communication Technology for Agricultural Engineering, 87621S (19 March 2013); https://doi.org/10.1117/12.2019682

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KEYWORDS

Bone

Minerals

Coating

Polymers

Titanium

Dual energy x-ray absorptiometry

Statistical analysis

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