Statistical analysis of surrogate signals to incorporate respiratory motion variability into radiotherapy treatment planning

Matthias Wilms; Jan Ehrhardt; René Werner; Mirko Marx; Heinz Handels

doi:10.1117/12.2043568

12 March 2014 Statistical analysis of surrogate signals to incorporate respiratory motion variability into radiotherapy treatment planning

Matthias Wilms, Jan Ehrhardt, René Werner, Mirko Marx, Heinz Handels

Author Affiliations +

Proceedings Volume 9036, Medical Imaging 2014: Image-Guided Procedures, Robotic Interventions, and Modeling; 90360J (2014) https://doi.org/10.1117/12.2043568
Event: SPIE Medical Imaging, 2014, San Diego, California, United States

Abstract

Respiratory motion and its variability lead to location uncertainties in radiation therapy (RT) of thoracic and abdominal tumors. Current approaches for motion compensation in RT are usually driven by respiratory surrogate signals, e.g., spirometry. In this contribution, we present an approach for statistical analysis, modeling and subsequent simulation of surrogate signals on a cycle-by-cycle basis. The simulated signals represent typical patient-specific variations of, e.g., breathing amplitude and cycle period. For the underlying statistical analysis, all breathing cycles of an observed signal are consistently parameterized using approximating B-spline curves. Statistics on breathing cycles are then performed by using the parameters of the B-spline approximations. Assuming that these parameters follow a multivariate Gaussian distribution, realistic time-continuous surrogate signals of arbitrary length can be generated and used to simulate the internal motion of tumors and organs based on a patient-specific diffeomorphic correspondence model. As an example, we show how this approach can be employed in RT treatment planning to calculate tumor appearance probabilities and to statistically assess the impact of respiratory motion and its variability on planned dose distributions.

Citation Download Citation

Matthias Wilms, Jan Ehrhardt, René Werner, Mirko Marx, and Heinz Handels "Statistical analysis of surrogate signals to incorporate respiratory motion variability into radiotherapy treatment planning", Proc. SPIE 9036, Medical Imaging 2014: Image-Guided Procedures, Robotic Interventions, and Modeling, 90360J (12 March 2014); https://doi.org/10.1117/12.2043568

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