Performance evaluation of fluorescence tomography in a Siemens Inveon multimodality scanner

Yujie Lu; Chinmay Darne; I-Chih Tan; Banghe Zhu; John Rasmussen; Eva M. Sevick-Muraca

doi:10.1117/12.2057818

19 May 2014 Performance evaluation of fluorescence tomography in a Siemens Inveon multimodality scanner

Yujie Lu, Chinmay Darne, I-Chih Tan, Banghe Zhu, John Rasmussen, Eva M. Sevick-Muraca

Proceedings Volume 9155, Translational Biophotonics; 91551H (2014) https://doi.org/10.1117/12.2057818
Event: SPIE Translational Biophotonics, 2014, Houston, Texas, United States

Abstract

A tri-modal (PET/CT/Optical) small animal tomographic imaging system was developed by integrating our advanced non-contact intensified CCD (ICCD) frequency-domain fluorescence imaging components into a Siemens Inveon scanner. We performed a performance evaluation of the developed imaging system by using the developed regularization-free high-order radiative-transfer-based reconstruction algorithm and custom solid phantoms. Our results show that frequency-domain photon migration (FDPM) fluorescence tomography can achieve better tomographic images with less artifacts and more precise fluorescent source localization compared to the continuous-wave counterpart. The developed multimodal tomographic imaging system provides a powerful tool for translational biomedical research.

Citation Download Citation

Yujie Lu, Chinmay Darne, I-Chih Tan, Banghe Zhu, John Rasmussen, and Eva M. Sevick-Muraca "Performance evaluation of fluorescence tomography in a Siemens Inveon multimodality scanner", Proc. SPIE 9155, Translational Biophotonics, 91551H (19 May 2014); https://doi.org/10.1117/12.2057818

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