Cellphone based mobile colposcope for the evaluation of women with abnormal cervical cancer screening

Bruce S. Kahn; Alex J. Kass; Jill Waalen; David Levitz

doi:10.1117/12.2078260

12 March 2015 Cellphone based mobile colposcope for the evaluation of women with abnormal cervical cancer screening

Bruce S. Kahn, Alex J. Kass, Jill Waalen, David Levitz

Proceedings Volume 9314, Optics and Biophotonics in Low-Resource Settings; 93140C (2015) https://doi.org/10.1117/12.2078260
Event: SPIE BiOS, 2015, San Francisco, California, United States

Abstract

Objective: Compare an inexpensive cell-phone based Mobile Colposcope, with a standard colposcope in the evaluation of women with abnormal Pap smear screening. Methodology: The study was a prospective, parallel noninferiority trial. Thirty women underwent colposcopy for the evaluation of an abnormal Pap smear. After application of acetic acid, images of the cervix were obtained with both a standard colposcope and the Mobile Colposcope. An additional set of images using both devices were obtained using the red-free (green filter) mode. Eight experienced gynecologists then evaluated 100 paired images (plain and green filter) from two different sites in random order using a web based assessment program. After reviewing each set of paired images, the expert would make an assessment of: 1) normal (no biopsy/ random biopsy), or 2) abnormal. For abnormal images, the expert then electronically marked the site(s) on the image where a biopsy was recommended. In image analysis, the cervical image was divided into 12 radial sectors and the marked sites for biopsy on the matched pairs were compared. Matched pairs that were considered normal, or those where biopsy site recommendations were within +/- 30° were considered equivalent; unmatched biopsy sites were considered non-equivalent. Results were compared using Wilcoxon Matched Pairs Signed Ranks Test. Expert assessment of Mobile Colposcope images compared with assessment by standard colposcope is currently onging. Conclusions: if the Mobile Colposcope demonstrates non-inferiority to imaging obtained with a standard colposcope and due to its low cost, it has the potential help improve cervical cancer screening in low resource settings.

Citation Download Citation

Bruce S. Kahn, Alex J. Kass, Jill Waalen, and David Levitz "Cellphone based mobile colposcope for the evaluation of women with abnormal cervical cancer screening", Proc. SPIE 9314, Optics and Biophotonics in Low-Resource Settings, 93140C (12 March 2015); https://doi.org/10.1117/12.2078260

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KEYWORDS

Biopsy

Cervix

Cervical cancer

Cancer

Image analysis

Image filtering

Light emitting diodes

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