Evaluation of Gleason scores by photoacoustic spectral analysis

Guan Xu; Scott A. Tomlins; Javed Siddiqui; Mandy Davis; Lakshmi P. Kunju; John T. Wei; Xueding Wang

doi:10.1117/12.2078065

11 March 2015 Evaluation of Gleason scores by photoacoustic spectral analysis

Guan Xu, Scott A. Tomlins, Javed Siddiqui, Mandy Davis, Lakshmi P. Kunju, John T. Wei, Xueding Wang

Proceedings Volume 9323, Photons Plus Ultrasound: Imaging and Sensing 2015; 93231S (2015) https://doi.org/10.1117/12.2078065
Event: SPIE BiOS, 2015, San Francisco, California, United States

Abstract

Ultrasound (US) guided biopsy is the standard procedure for evaluating the presence of prostate cancer (PCa). The biopsied tissues are evaluated by a Gleason scoring system which quantifies the severity of prostate cancer based on the clustering patterns of the cancer cells. The clustering patterns can be visualized by staining the cancer cells with optical contrast enhancing nanoparticles (NPs). This study investigates the feasibility of evaluating the NP stained Gleason patterns using photoacoustic spectrum analysis (PASA), aiming toward achieving minimally invasive prostate biopsy. The experiment on H&E stained human prostate tissue slices demonstrates that this approach is capable of identifying and potentially grading PCa.

Citation Download Citation

Guan Xu, Scott A. Tomlins, Javed Siddiqui, Mandy Davis, Lakshmi P. Kunju, John T. Wei, and Xueding Wang "Evaluation of Gleason scores by photoacoustic spectral analysis", Proc. SPIE 9323, Photons Plus Ultrasound: Imaging and Sensing 2015, 93231S (11 March 2015); https://doi.org/10.1117/12.2078065

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