Dynamic evaluation and control of blood clotting using a microfluidic platform for high-throughput diagnostics

Miguel E. Combariza; Xinghuo Yu; Warwick Nesbitt; Francisco Tovar-Lopez; Dominik G. Rabus; Arnan Mitchell

doi:10.1117/12.2202367

22 December 2015 Dynamic evaluation and control of blood clotting using a microfluidic platform for high-throughput diagnostics

Miguel E. Combariza, Xinghuo Yu, Warwick Nesbitt, Francisco Tovar-Lopez, Dominik G. Rabus, Arnan Mitchell

Author Affiliations +

Proceedings Volume 9668, Micro+Nano Materials, Devices, and Systems; 96681U (2015) https://doi.org/10.1117/12.2202367
Event: SPIE Micro+Nano Materials, Devices, and Applications, 2015, Sydney, New South Wales, Australia

Abstract

Microfluidic technology has the potential to revolutionise blood-clotting diagnostics by incorporating key physiological blood flow conditions like shear rate. In this paper we present a customised dynamic microfluidic system, which evaluates the blood clotting response to multiple conditions of shear rate on a single microchannel. The system can achieve high-throughput testing through use of an advanced fluid control system, which provides with rapid and precise regulation of the blood flow conditions in the platform. We present experimental results that demonstrate the potential of this platform to develop into a high-throughput, low-cost, blood-clotting diagnostics device.

Citation Download Citation

Miguel E. Combariza, Xinghuo Yu, Warwick Nesbitt, Francisco Tovar-Lopez, Dominik G. Rabus, and Arnan Mitchell "Dynamic evaluation and control of blood clotting using a microfluidic platform for high-throughput diagnostics", Proc. SPIE 9668, Micro+Nano Materials, Devices, and Systems, 96681U (22 December 2015); https://doi.org/10.1117/12.2202367

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