Feasibility of OCT to detect radiation-induced esophageal damage in small animal models (Conference Presentation)

Pouya Jelvehgaran; Tanja Alderliesten; Javier Salguero; Gerben Borst; Ji-Ying Song; Ton G. van Leeuwen; Johannes F. de Boer; Daniel M. de Bruin; Marcel B. van Herk

doi:10.1117/12.2210829

27 April 2016 Feasibility of OCT to detect radiation-induced esophageal damage in small animal models (Conference Presentation)

Pouya Jelvehgaran, Tanja Alderliesten, Javier Salguero, Gerben Borst, Ji-Ying Song, Ton G. van Leeuwen, Johannes F. de Boer, Daniel M. de Bruin, Marcel B. van Herk

Author Affiliations +

Proceedings Volume 9691, Endoscopic Microscopy XI; and Optical Techniques in Pulmonary Medicine III; 96910S (2016) https://doi.org/10.1117/12.2210829
Event: SPIE BiOS, 2016, San Francisco, California, United States

Abstract

Lung cancer survival is poor and radiotherapy patients often suffer serious treatment side effects. The esophagus is particularly sensitive leading to reduced food intake or even fistula formation. Only few direct techniques exist to measure radiation-induced esophageal damage, for which knowledge is needed to improve the balance between risk of tumor recurrence and complications. Optical coherence tomography (OCT) is a minimally-invasive imaging technique that obtains cross-sectional, high-resolution (1-10µm) images and is capable of scanning the esophageal wall up to 2-3mm depth. In this study we investigated the feasibility of OCT to detect esophageal radiation damage in mice. In total 30 mice were included in 4 study groups (1 main and 3 control groups). Mice underwent cone-beam CT imaging for initial setup assessment and dose planning followed by single-fraction dose delivery of 4, 10, 16, and 20Gy on 5mm spots, spaced 10mm apart. Mice were repeatedly imaged using OCT: pre-irradiation and up to 3 months post-irradiation. The control groups received either OCT only, irradiation only, or were sham-operated. We used histopathology as gold standard for radiation-induced damage diagnosis. The study showed edema in both the main and OCT-only groups. Furthermore, radiation-induced damage was primarily found in the highest dose region (distal esophagus). Based on the histopathology reports we were able to identify the radiation-induced damage in the OCT images as a change in tissue scattering related to the type of induced damage. This finding indicates the feasibility and thereby the potentially promising role of OCT in radiation-induced esophageal damage assessment.

Conference Presentation

Citation Download Citation

Pouya Jelvehgaran, Tanja Alderliesten, Javier Salguero, Gerben Borst, Ji-Ying Song, Ton G. van Leeuwen, Johannes F. de Boer, Daniel M. de Bruin, and Marcel B. van Herk "Feasibility of OCT to detect radiation-induced esophageal damage in small animal models (Conference Presentation)", Proc. SPIE 9691, Endoscopic Microscopy XI; and Optical Techniques in Pulmonary Medicine III, 96910S (27 April 2016); https://doi.org/10.1117/12.2210829

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KEYWORDS

Optical coherence tomography

Animal model studies

Esophagus

Computed tomography

Gold

Lung cancer

Radiotherapy

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