Preliminary studies of fluorescence image-guided photothermal therapy of human oesophageal adenocarcinoma in vivo using multifunctional gold nanorods

Elham Nabavi; Mohan Singh; Yu Zhou; Maria Elena Gallina; Hailin Zhao; Daqing Ma; Anthony Cass; George Hanna; Daniel S. Elson

doi:10.1117/12.2212337

1 March 2016 Preliminary studies of fluorescence image-guided photothermal therapy of human oesophageal adenocarcinoma in vivo using multifunctional gold nanorods

Elham Nabavi, Mohan Singh, Yu Zhou, Maria Elena Gallina, Hailin Zhao, Daqing Ma, Anthony Cass, George Hanna, Daniel S. Elson

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Proceedings Volume 9694, Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy XXV; 96940G (2016) https://doi.org/10.1117/12.2212337
Event: SPIE BiOS, 2016, San Francisco, California, United States

Abstract

We present a preliminary in vivo study of fluorescence imaging and photothermal therapy (PTT) of human oesophageal adenocarcinoma using multi-functionalised gold nanorods (GNRs). After establishing tumour xenograft in mouse functionalised GNRs were administrated intravenously (IV). Fluorescence imaging was performed to detect the tumour area. The intensity of the fluorescence signal varied significantly across the tumour site and surrounding tissues. PTT was then performed using a 808 nm continuous wave diode laser to irradiate the tumour for 3 minutes, inducing a temperature rise of ~44°C, which photothermally ablated the tumour.

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Elham Nabavi, Mohan Singh, Yu Zhou, Maria Elena Gallina, Hailin Zhao, Daqing Ma, Anthony Cass, George Hanna, and Daniel S. Elson "Preliminary studies of fluorescence image-guided photothermal therapy of human oesophageal adenocarcinoma in vivo using multifunctional gold nanorods", Proc. SPIE 9694, Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy XXV, 96940G (1 March 2016); https://doi.org/10.1117/12.2212337

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KEYWORDS

Luminescence

Gold

In vivo imaging

Nanorods

Near infrared

Tissues

Cameras

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