Comparison of production methods of a spiral inertial microfluidic cell separation device

Mitchell Robinson; Haley Marks; Gerard L. Coté

doi:10.1117/12.2213894

4 March 2016 Comparison of production methods of a spiral inertial microfluidic cell separation device

Mitchell Robinson, Haley Marks, Gerard L. Coté

Proceedings Volume 9715, Optical Diagnostics and Sensing XVI: Toward Point-of-Care Diagnostics; 97151C (2016) https://doi.org/10.1117/12.2213894
Event: SPIE BiOS, 2016, San Francisco, California, United States

Abstract

From the miniaturization of large sample processing machines to the creation of handheld point-of-care devices, microfluidics has the potential to be a powerful tool in the advancement of diagnostic technologies. Here, we compare different prototyping modalities towards the generation of an inertial microfluidic blood filter: i.e. a 'centrifuge-on-a-chip'. While photolithography is currently the method of choice for soft lithography mold fabrication, offering high design fidelity, we believe simpler methods, such as milling or 3D printing, will soon become equally viable options in the field of microfluidic device fabrication. Three modalities for optofluidic PDMS chip fabrication were compared: micromachining, 3D printing, and SU8 photolithography. The filtration efficiency of the chips were tested with whole blood and compared spectroscopically by monitoring the outlet absorbance at the 540 nm peak intrinsic to oxyhemoglobin at the outlet of each filter chip.

Citation Download Citation

Mitchell Robinson, Haley Marks, and Gerard L. Coté "Comparison of production methods of a spiral inertial microfluidic cell separation device", Proc. SPIE 9715, Optical Diagnostics and Sensing XVI: Toward Point-of-Care Diagnostics, 97151C (4 March 2016); https://doi.org/10.1117/12.2213894

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