Portable microscopy platform for the clinical and environmental monitoring

Weiming Wang; Yan Yu; Hui Huang; Jinping Ou

doi:10.1117/12.2219114

16 April 2016 Portable microscopy platform for the clinical and environmental monitoring

Weiming Wang, Yan Yu, Hui Huang, Jinping Ou

Proceedings Volume 9802, Nanosensors, Biosensors, and Info-Tech Sensors and Systems 2016; 98021P (2016) https://doi.org/10.1117/12.2219114
Event: SPIE Smart Structures and Materials + Nondestructive Evaluation and Health Monitoring, 2016, Las Vegas, Nevada, United States

Abstract

Light microscopy can not only address various diagnosis needs such as aquatic parasites and bacteria such as E. coli in water, but also provide a method for the screening of red tide. Traditional microscope based on the smartphone created by adding lens couldn’t keep the tradeoff between field-of-view(FOV) and the resolution. In this paper, we demonstrate a non-contact, light and cost-effective microscope platform, that can image highly dense samples with a spatial resolution of ~0.8um over a field-of-view(FOV) of >1mm². After captured the direct images, we performed the pixel super-resolution algorithm to improve the image resolution and overcome the hardware interference. The system would be a good point-of-care diagnostic solution in resource limited settings. We validated the performance of the system by imaging resolution test targets, the squamous cell cancer(SqCC) and green algae that necessary to detect the squamous carcinoma and red tide

Citation Download Citation

Weiming Wang, Yan Yu, Hui Huang, and Jinping Ou "Portable microscopy platform for the clinical and environmental monitoring", Proc. SPIE 9802, Nanosensors, Biosensors, and Info-Tech Sensors and Systems 2016, 98021P (16 April 2016); https://doi.org/10.1117/12.2219114

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