Light-based theranostics using hybrid structures derived from biological and organic materials

Raviraj Vankayala; Joshua M. Burns; Jenny T. Mac; Bahman Anvari

doi:10.1117/12.2238406

27 September 2016 Light-based theranostics using hybrid structures derived from biological and organic materials

Raviraj Vankayala, Joshua M. Burns, Jenny T. Mac, Bahman Anvari

Proceedings Volume 9930, Biosensing and Nanomedicine IX; 993008 (2016) https://doi.org/10.1117/12.2238406
Event: SPIE Nanoscience + Engineering, 2016, San Diego, California, United States

Abstract

We have engineered hybrid nanostructures derived from erythrocytes, which can be doped with various near infrared (NIR) organic chromophores, including the FDA-approved indocyanine green (ICG). We refer to these vesicles as NIR erythrocyte-mimicking transducers (NETs), as they are capable of generating heat, reactive oxygen species (ROS) or emit fluorescence light. We present preliminary results that demonstrate the effectiveness of NETs for fluorescence imaging and photodynamic therapeutic destruction of breast cancer cells, upon photo-excitation using NIR light. These hybrid nanostructures present a promising platform with theranostic capability for future biomedical clinical applications.

Conference Presentation

Citation Download Citation

Raviraj Vankayala, Joshua M. Burns, Jenny T. Mac, and Bahman Anvari "Light-based theranostics using hybrid structures derived from biological and organic materials", Proc. SPIE 9930, Biosensing and Nanomedicine IX, 993008 (27 September 2016); https://doi.org/10.1117/12.2238406

ACCESS THE FULL ARTICLE

INSTITUTIONAL
Select your institution to access the SPIE Digital Library.

SELECT YOUR INSTITUTION

PERSONAL
Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.

PERSONAL SIGN IN

No SPIE Account? Create one

PURCHASE THIS CONTENT

SUBSCRIBE TO DIGITAL LIBRARY

50 downloads per 1-year subscription

Members: $195

Non-members: $335 ADD TO CART

25 downloads per 1 - year subscription

Members: $145

Non-members: $250 ADD TO CART

PURCHASE SINGLE ARTICLE

Includes PDF, HTML & Video, when available