Precise monitoring of skin cellular changes in vivo at the same micro-location over a long period of weeks using MPM based multimodality microscopy

Yunxian (Giselle) Tian; Zhenguo Wu; Harvey Lui; Jianhua Zhao; Sunil Kalia; Haishan Zeng

doi:10.1117/12.2615707

7 March 2022 Precise monitoring of skin cellular changes in vivo at the same micro-location over a long period of weeks using MPM based multimodality microscopy

Yunxian (Giselle) Tian, Zhenguo Wu, Harvey Lui, Jianhua Zhao, Sunil Kalia, Haishan Zeng

Author Affiliations +

Proceedings Volume PC11934, Photonics in Dermatology and Plastic Surgery 2022; PC1193406 (2022) https://doi.org/10.1117/12.2615707
Event: SPIE BiOS, 2022, San Francisco, California, United States

Abstract

Summary: We developed a fully automated microregistration method that enables repeated in vivo skin microscopy imaging of the same tissue microlocation and specific cells over a long period of days and weeks with unprecedented precision. Applying this method in conjunction with in vivo multimodality multiphoton microscope, the behavior of human skin cells such as cell proliferation, melanin upward migration, blood flow dynamics, and epidermal thickness adaptation can be recorded over time, facilitating quantitative cellular dynamics analysis.

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Yunxian (Giselle) Tian, Zhenguo Wu, Harvey Lui, Jianhua Zhao, Sunil Kalia, and Haishan Zeng "Precise monitoring of skin cellular changes in vivo at the same micro-location over a long period of weeks using MPM based multimodality microscopy", Proc. SPIE PC11934, Photonics in Dermatology and Plastic Surgery 2022, PC1193406 (7 March 2022); https://doi.org/10.1117/12.2615707

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KEYWORDS

Skin

In vivo imaging

Microscopy

Imaging systems

Confocal microscopy

Two photon imaging

Signal analyzers

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