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7 March 2022 Guide the control and treatment of carbapenem-resistant bacterial infections with FIBA
Yanfang Feng, Shoaib Ashraf, Tayyaba Hasan
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Proceedings Volume PC11939, Photonic Diagnosis, Monitoring, Prevention, and Treatment of Infections and Inflammatory Diseases 2022; PC1193901 (2022) https://doi.org/10.1117/12.2607887
Event: SPIE BiOS, 2022, San Francisco, California, United States
Abstract
Rapid and accurate diagnosis and subtyping of bacterial carbapenemases are urgently needed due to the increasing prevalence of carbapenem-resistant bacterial infections. By mixing bacteria with a fluorescent probe, β-LEAF (β-lactamase enzyme activated fluorophore), together with three β-lactamase inhibitors ( imipenem for noncarbapenemase β-lactamases, clavulanic acid for type A carbapenemases, and EDTA for type B carbapenemase), we developed a FIBA (Fluorescence Identification of β-Lactamase Activity) platform, which can generate a 95% - 100% sensitivity and specificity for carbapenemase diagnosis and classification within 10 minutes by a single mixing step. FIBA could significantly aid the control and treatment of carbapenem-resistant bacterial infections.
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Yanfang Feng, Shoaib Ashraf, and Tayyaba Hasan "Guide the control and treatment of carbapenem-resistant bacterial infections with FIBA", Proc. SPIE PC11939, Photonic Diagnosis, Monitoring, Prevention, and Treatment of Infections and Inflammatory Diseases 2022, PC1193901 (7 March 2022); https://doi.org/10.1117/12.2607887
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KEYWORDS
Bacteria
Luminescence
Medicine
Pathogens
Resistance
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