Full-field swept source optical coherence tomography (FF-SS-OCT) system for in vivo evaluation of light evoked activation of photoreceptors (optoretinography) in mice

Robert J. Zawadzki; Denise Valente; Ratheesh K. Meleppat; Kari V. Vienola; Sarah J. Karlen; Pengfei Zhang; Ravi S. Jonnal; Nathan P. Doble

doi:10.1117/12.2609714

7 March 2022 Full-field swept source optical coherence tomography (FF-SS-OCT) system for in vivo evaluation of light evoked activation of photoreceptors (optoretinography) in mice

Robert J. Zawadzki, Denise Valente, Ratheesh K. Meleppat, Kari V. Vienola, Sarah J. Karlen, Pengfei Zhang, Ravi S. Jonnal, Nathan P. Doble

Author Affiliations +

Proceedings Volume PC11941, Ophthalmic Technologies XXXII; PC119410G (2022) https://doi.org/10.1117/12.2609714
Event: SPIE BiOS, 2022, San Francisco, California, United States

Abstract

Development of high resolution functional retinal imaging tools is of great interest to clinical and experimental ophthalmology because the alterations in retinal function, at cellular resolution, hold the promise of being more sensitive for disease diagnostic then the purely retinal morphology-based assays. In this work we present our initial design and implementation of mouse retinal imaging system that incorporates full-field (FF) swept- source (SS) optical coherence tomography (OCT) with dedicated light stimulation channel for high-speed measurements of light evoked responses in photoreceptors of mice. The Optoretinograpahy (ORG) results acquired with our FF-SS-OCT system are compared with those acquired with our standard raster scanning mouse ORG-OCT system.

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Robert J. Zawadzki, Denise Valente, Ratheesh K. Meleppat, Kari V. Vienola, Sarah J. Karlen, Pengfei Zhang, Ravi S. Jonnal, and Nathan P. Doble "Full-field swept source optical coherence tomography (FF-SS-OCT) system for in vivo evaluation of light evoked activation of photoreceptors (optoretinography) in mice", Proc. SPIE PC11941, Ophthalmic Technologies XXXII, PC119410G (7 March 2022); https://doi.org/10.1117/12.2609714

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