Optical methods for non-invasive assessment of cerebral microvascular flow impedance

Jason Yang; Deepshikha Acharya; Bradley Scammon; Samantha Schmitt; Matthew A. Smith; Jana M. Kainerstorfer

doi:10.1117/12.2609917

7 March 2022 Optical methods for non-invasive assessment of cerebral microvascular flow impedance

Jason Yang, Deepshikha Acharya, Bradley Scammon, Samantha Schmitt, Matthew A. Smith, Jana M. Kainerstorfer

Proceedings Volume PC11945, Clinical and Translational Neurophotonics 2022; PC1194501 (2022) https://doi.org/10.1117/12.2609917
Event: SPIE BiOS, 2022, San Francisco, California, United States

Abstract

Vascular impedance is a frequency dependent quantity relating a vascular compartment's flow dynamics to pressure changes. Although vascular impedance has been investigated in larger arteries using Doppler ultrasound, probing the smaller microvasculature using similar techniques is difficult due to their small cross-sectional area. However, recent developments using diffuse optics have enabled the possibility of measuring blood flow and volume in arterioles and other microvasculature. This research presents a method to estimate the arteriole impedance non-invasively using diffuse correlation spectroscopy (DCS) as well as near-infrared spectroscopy (NIRS).

Conference Presentation

Citation Download Citation

Jason Yang, Deepshikha Acharya, Bradley Scammon, Samantha Schmitt, Matthew A. Smith, and Jana M. Kainerstorfer "Optical methods for non-invasive assessment of cerebral microvascular flow impedance", Proc. SPIE PC11945, Clinical and Translational Neurophotonics 2022, PC1194501 (7 March 2022); https://doi.org/10.1117/12.2609917

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