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9 March 2022 High-resolution intranasal micro-optical coherence tomography (μOCT) imaging of Covid-19 positive human subjects
Hui Min Leung, Kadambari Vijaykumar, George M. Solomon, Amilcar Barrios, Susan E. Birket, Heather Y. Hathorne, Justin D. Wade, Kathryn Monroe, Katie B. Slaten, Sam Foster, Doug Marsden, Paul Currier, Kristian Olson, Steven M. Rowe, Guillermo J. Tearney
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Proceedings Volume PC11949, Advanced Biomedical and Clinical Diagnostic and Surgical Guidance Systems XX; PC119490E (2022) https://doi.org/10.1117/12.2607192
Event: SPIE BiOS, 2022, San Francisco, California, United States
Abstract
Since the recognition that entry factors of SARS-CoV-2 are highly expressed in the nasal epithelium, a custom personal protection booth was developed to enable intranasal µOCT studies to be safely performed on Covid-positive subjects. The booth was designed to preserve familiarity of the prior established intranasal imaging techniques used by clinicians. A group of Covid-positive subjects (n=13) were imaged, shortly after onset of symptoms (7.8 ± 3.7 days). Historical data from healthy controls (n=10) were included in the study. While the blinded analysis is underway, an interim analysis of the µOCT data revealed several notable abnormalities in the nasal epithelium including delayed mucociliary transport, epithelial injury, and high inflammatory cell count in a pilot cohort. We anticipate that the pathophysiologies captured by intranasal µOCT will provide invaluable insights to the mechanisms of Covid-19 related mucociliary dysfunction.
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Hui Min Leung, Kadambari Vijaykumar, George M. Solomon, Amilcar Barrios, Susan E. Birket, Heather Y. Hathorne, Justin D. Wade, Kathryn Monroe, Katie B. Slaten, Sam Foster, Doug Marsden, Paul Currier, Kristian Olson, Steven M. Rowe, and Guillermo J. Tearney "High-resolution intranasal micro-optical coherence tomography (μOCT) imaging of Covid-19 positive human subjects", Proc. SPIE PC11949, Advanced Biomedical and Clinical Diagnostic and Surgical Guidance Systems XX, PC119490E (9 March 2022); https://doi.org/10.1117/12.2607192
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KEYWORDS
Coherence imaging
Human subjects
Tomography
Coherence (optics)
Control systems
In vivo imaging
Pathophysiology
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