Novel optical imaging methods for photoimmunotherapy monitoring

Qinggong Tang; Feng Yan; Chen Wang; Shulian Wu; Ryuhei Okada; Tadanobu Nagaya; Yuhong Fang; Hui Li; Yu Chen; Hisataka Kobayashi

doi:10.1117/12.2607879

7 March 2022 Novel optical imaging methods for photoimmunotherapy monitoring

Qinggong Tang, Feng Yan, Chen Wang, Shulian Wu, Ryuhei Okada, Tadanobu Nagaya, Yuhong Fang, Hui Li, Yu Chen, Hisataka Kobayashi

Author Affiliations +

Proceedings Volume PC11961, Biophotonics and Immune Responses XVII; PC1196106 (2022) https://doi.org/10.1117/12.2607879
Event: SPIE BiOS, 2022, San Francisco, California, United States

Abstract

Near-infrared photoimmunotherapy (NIR-PIT) is an emerging cancer therapy based on conjugating monoclonal antibody (mAb) with a NIR phthalocyanine dye conjugate. Direct tumor necrosis and immunogenic cell death occur during NIR irradiation. We applied a multi-modal optical imaging approach including high-resolution optical coherence tomography (OCT) and high-sensitivity fluorescence mesoscopic tomography, to provide 3D tumor micro-structure and micro-distribution of mAb-IR700 in the tumor simultaneously during and after NIR-PIT in situ and in vivo. Moreover, label-free speckle variance algorithm combined OCT was applied to monitor the change of blood vessels and the alterations of the blood volume inside the blood vessels during and NIR-PIT treatment.

Conference Presentation

Citation Download Citation

Qinggong Tang, Feng Yan, Chen Wang, Shulian Wu, Ryuhei Okada, Tadanobu Nagaya, Yuhong Fang, Hui Li, Yu Chen, and Hisataka Kobayashi "Novel optical imaging methods for photoimmunotherapy monitoring", Proc. SPIE PC11961, Biophotonics and Immune Responses XVII, PC1196106 (7 March 2022); https://doi.org/10.1117/12.2607879

ACCESS THE FULL ARTICLE

INSTITUTIONAL
Select your institution to access the SPIE Digital Library.

SELECT YOUR INSTITUTION

PERSONAL
Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.

PERSONAL SIGN IN

No SPIE Account? Create one

PURCHASE THIS CONTENT

SUBSCRIBE TO DIGITAL LIBRARY

50 downloads per 1-year subscription

Members: $195

Non-members: $335 ADD TO CART

25 downloads per 1 - year subscription

Members: $145

Non-members: $250 ADD TO CART

PURCHASE SINGLE ARTICLE

Includes PDF, HTML & Video, when available

Members: $17.00

Non-members: $21.00 ADD TO CART

PROCEEDINGS
PRESENTATION

WATCH
PRESENTATION SAVE TO MY LIBRARY

GET CITATION

KEYWORDS

Optical imaging

Photoimmunotherapy

Blood vessels

Tumors

3D image processing

Blood

Near infrared

Show All Keywords

Keywords/Phrases

Search In:

Publication Years