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7 March 2022 Polarimentric differentiation of ex vivo colon samples complemented by machine-learning
Deyan Ivanov, Viktor Dremin, Tsanislava Genova, Alexander Bykov, Igor Meglinski, Tatiana Novikova, Razvigor Ossikovski
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Proceedings Volume PC11963, Polarized Light and Optical Angular Momentum for Biomedical Diagnostics 2022; PC1196307 (2022) https://doi.org/10.1117/12.2615297
Event: SPIE BiOS, 2022, San Francisco, California, United States
Abstract
We present a combination of Mueller matrix measurements (635 nm) of cancerous colon specimens and machine-learning approach. Physical realizability filtering and symmetric decomposition were used to extract polarimetric quantities, used as predictors in machine-learning algorithms. The results were visualized using various depolarization spaces. Principal component analysis was used to extract particular features from the model, logistic regression evaluated predictors with high likelihood for tumor detection, while random forest and support vector machines provided the best results for classification. Hence, polarimetry combined with machine-learning approach may increase the histopathology diagnostic accuracy.
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Deyan Ivanov, Viktor Dremin, Tsanislava Genova, Alexander Bykov, Igor Meglinski, Tatiana Novikova, and Razvigor Ossikovski "Polarimentric differentiation of ex vivo colon samples complemented by machine-learning", Proc. SPIE PC11963, Polarized Light and Optical Angular Momentum for Biomedical Diagnostics 2022, PC1196307 (7 March 2022); https://doi.org/10.1117/12.2615297
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KEYWORDS
Polarimetry
Colon
Tissue optics
Diagnostics
Optical spheres
Polarization
Principal component analysis
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