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2 March 2022 Smart breast clip: A wireless implant for continuous molecular sensing of breast masses
Alicia Y. Wei, Gregory Moore, Kedi Yan, Brody Mahoney, Joshua R Smith, Thomas D. O'Sullivan
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Proceedings Volume PC11972, Label-free Biomedical Imaging and Sensing (LBIS) 2022; PC1197215 (2022) https://doi.org/10.1117/12.2607241
Event: SPIE BiOS, 2022, San Francisco, California, United States
Abstract
We present a minimally invasive, needle-injectable, wirelessly-powered diffuse optical spectroscopy sensor implant that fits within a 12G breast biopsy needle. The sensor uses red and near-infrared lasers to measure tumor hemoglobin concentration changes. It contains two photodiodes controlled by an analog front end integrated circuit with an integrated transimpedance amplifier. This ultralow power sensor is wirelessly powered using near-field resonant inductive coupling and communicates via backscattered load shift keying. Characterization in liquid tissue mimicking phantoms showed a response to absorption concentrations consistent with estimated tumor hemoglobin concentrations. After implantation in murine breast cancer models, tissue stainings revealed no adverse effects.
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Alicia Y. Wei, Gregory Moore, Kedi Yan, Brody Mahoney, Joshua R Smith, and Thomas D. O'Sullivan "Smart breast clip: A wireless implant for continuous molecular sensing of breast masses", Proc. SPIE PC11972, Label-free Biomedical Imaging and Sensing (LBIS) 2022, PC1197215 (2 March 2022); https://doi.org/10.1117/12.2607241
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KEYWORDS
Breast
Tumors
Sensors
Breast cancer
Tissues
Ranging
Resistance
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