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17 March 2023 Drug resistant cancer cells exhibit increased protoporphyrin IX accumulation and improved PDT response following 5-aminolevulinic acid photosensitization
Yiran Liu, Michael Anderson, Sally Kyei Mensah, Sergio Farias, Maryam Labaf, Kourosh Zarringhalam, Shakir Khan, Tayyaba Hasan, Jonathan Celli
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Proceedings Volume PC12359, Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy XXXI; PC1235902 (2023) https://doi.org/10.1117/12.2651500
Event: SPIE BiOS, 2023, San Francisco, California, United States
Abstract
Administration of 5-aminolevulinic acid (ALA) as a precursor for protoporphyrin IX (PpIX) is an established photosensitization strategy for photodynamic therapy (PDT) and fluorescence guided surgery. Ongoing studies seek to identify strategies to enhance PpIX accumulation as well as phenotypic traits that correlate with high PpIX conversion. Here we examine PpIX accumulation, PDT response, and differential gene expression in pancreatic and oral cancer cells compared to derivative sublines with acquired drug resistance. The latter exhibit poor differentiation and increased EMT but marked increase in PpIX conversion and enhanced response to PDT. RNAseq analysis shows dramatic changes in expression of genes relevant to PpIX transport (ABCG2) and PpIX formation (ALAD).
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Yiran Liu, Michael Anderson, Sally Kyei Mensah, Sergio Farias, Maryam Labaf, Kourosh Zarringhalam, Shakir Khan, Tayyaba Hasan, and Jonathan Celli "Drug resistant cancer cells exhibit increased protoporphyrin IX accumulation and improved PDT response following 5-aminolevulinic acid photosensitization", Proc. SPIE PC12359, Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy XXXI, PC1235902 (17 March 2023); https://doi.org/10.1117/12.2651500
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KEYWORDS
Photodynamic therapy
Cancer
Tissues
Biology
Luminescence
Resistance
Surgery
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