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Measurement of visual function plays a critical role in assessing the health of the retina. Optoretinography (ORG) is an emerging technique for noninvasive measurement of retinal neural function. Recent efforts have demonstrated the feasibility of the ORG using advanced OCT systems which track single cells in the retina and measure the stimulus-evoked movement of their subcellular features. Here we demonstrate a novel velocity-based approach in three healthy subjects. The resulting responses were reproducible, exhibited expected dependence on dose and retinal eccentricity, and could be related to earlier position-based methods through numerical integration.
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Reddikumar Maddipatla, Kari V. Vienola, Robert J. Zawadzki, Ravi S. Jonnal, "Clinical optoretinography using OCT phase velocity," Proc. SPIE PC12360, Ophthalmic Technologies XXXIII, PC123600C (17 March 2023); https://doi.org/10.1117/12.2649401