Cross-meridian air-puff deformation OCT for improved detection of early stage keratoconus

Judith S. Birkenfeld; Andrea Curatolo; Ashkan Eliasy; Alejandra Varea; Eduardo Martinez Enriquez; Bernardo Lopes Teixeira; Ahmed Abass; Nicolas Alejandre-Alba; Jesus Merayo-Lloves; Ahmed Elsheikh; Susana Marcos

doi:10.1117/12.2649770

17 March 2023 Cross-meridian air-puff deformation OCT for improved detection of early stage keratoconus

Judith S. Birkenfeld, Andrea Curatolo, Ashkan Eliasy, Alejandra Varea, Eduardo Martinez Enriquez, Bernardo Lopes Teixeira, Ahmed Abass, Nicolas Alejandre-Alba, Jesus Merayo-Lloves, Ahmed Elsheikh, Susana Marcos

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Proceedings Volume PC12360, Ophthalmic Technologies XXXIII; PC123600M (2023) https://doi.org/10.1117/12.2649770
Event: SPIE BiOS, 2023, San Francisco, California, United States

Abstract

Corneal biomechanical weakening presumably precedes keratoconus (KC), an ocular disease that leads to vision loss. Cross-meridian swept-source OCT coupled to air-puff excitation was used to induce corneal deformation to investigate biomechanics in Forme Fruste (FF)/subclinical (n=10), KC I (n=10) and healthy (n=12) eyes. Shape and asymmetry deformation parameters were analyzed in two meridians, and the tangent modulus was calculated using Finite Element modeling (FEM). Compared to healthy eyes, the asymmetry parameter decreased 0.32±0.05% (FF/subclinical), and 0.66±0.18% (KC I). The shape parameter increased 0.91±0.32% (FF/subclinical) and 1.47±1.2% (KC I). Significant differences between groups were observed mostly on the vertical meridian. Inverse FEM showed ∼30% localized stiffness reduction in KC eyes, compared to healthy eyes. Our results show that the additional vertical meridian allows more significant use of deformation parameters as biomarkers of biomechanical changes.

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Judith S. Birkenfeld, Andrea Curatolo, Ashkan Eliasy, Alejandra Varea, Eduardo Martinez Enriquez, Bernardo Lopes Teixeira, Ahmed Abass, Nicolas Alejandre-Alba, Jesus Merayo-Lloves, Ahmed Elsheikh, and Susana Marcos "Cross-meridian air-puff deformation OCT for improved detection of early stage keratoconus", Proc. SPIE PC12360, Ophthalmic Technologies XXXIII, PC123600M (17 March 2023); https://doi.org/10.1117/12.2649770

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KEYWORDS

Optical coherence tomography

Finite element methods

Data modeling

Cornea

Eye models

Pathology

Shape analysis

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