Detecting subclinical keratoconus by mapping corneal biomechanics using wave-based optical coherence elastography

Fernando Zvietcovich; Alejandra Varea; Nicolas Alejandre-Alba; Jesus Merayo-Lloves; Judith S. Birkenfeld; Susana Marcos

doi:10.1117/12.2649414

17 March 2023 Detecting subclinical keratoconus by mapping corneal biomechanics using wave-based optical coherence elastography

Fernando Zvietcovich, Alejandra Varea, Nicolas Alejandre-Alba, Jesus Merayo-Lloves, Judith S. Birkenfeld, Susana Marcos

Author Affiliations +

Proceedings Volume PC12360, Ophthalmic Technologies XXXIII; PC123600O (2023) https://doi.org/10.1117/12.2649414
Event: SPIE BiOS, 2023, San Francisco, California, United States

Abstract

The detection of subclinical keratoconus in human corneas remains a challenging task. We propose to use a wave-based air-coupled ultrasonic optical coherence elastography system to map the elasticity of the corneas of 15 patients with a clinical diagnosis of keratoconus (KC) in one eye, and subclinical keratoconus (SK) in the fellow eye. Two biomarkers are proposed: Spatial Anisotropy of Wave Speed (SAWS), and the Speed-Thickness Index (STI). Our results show important biomechanical differences between normal, subclinical, and advanced stages of keratoconus, suggesting SAWS and STI as potential biomarkers to identify “at-risk” corneas before changes in topography and pachymetry become evident.

Conference Presentation

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Fernando Zvietcovich, Alejandra Varea, Nicolas Alejandre-Alba, Jesus Merayo-Lloves, Judith S. Birkenfeld, and Susana Marcos "Detecting subclinical keratoconus by mapping corneal biomechanics using wave-based optical coherence elastography", Proc. SPIE PC12360, Ophthalmic Technologies XXXIII, PC123600O (17 March 2023); https://doi.org/10.1117/12.2649414

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