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Gold nanostars (GNS) have increasingly seen usage in photothermal treatment of diseases such as cancer. Owing to their flexible synthesis, GNS can be easily tuned to absorption wavelengths that bypass the absorption of non-target tissue. The particles can also be easily coupled with other sensing modalities such as molecular imaging using surface-enhanced Raman spectroscopy (SERS) and Immunotherapy in a synergistic manner. We have developed a combination treatment for cancer therapy called Synergistic Immuno Photo Nanotherapy (SYMPHONY) effectively uses photothermal heating as an adjunct treatment with immune check-point inhibitors. Here we develop several methods to simulate and analyze the optical and thermal effects of GNS absorption. In particular, the optimal conditions of GNS heating are investigated for understanding specific targeted therapy with limitations surrounding tissue absorption.
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Ren A. Odion, Yang Liu, Stephen J. Norton, Tuan Vo-Dinh, "Multiplatform and synergetic photothermal heating using plasmonic gold nanostars," Proc. SPIE PC12368, Advanced Biomedical and Clinical Diagnostic and Surgical Guidance Systems XXI, PC123680Q (31 March 2023); https://doi.org/10.1117/12.2650598