Current approaches of creating optical phantoms cannot accurately capture the wavelength-dependent properties found in tissue. To address this, we developed a method of producing solid, inorganic phantoms whose wavelength-dependent optical properties can be fit to those of tissue over 370 to 950 nm through the combination of up to twenty different absorbing and scattering pigments. Using this approach, we were able to create and validate spectral phantoms closely matching the optical properties of muscle and nerve tissue, the diffuse reflectance of pale and melanistic skin, and the chromophore concentrations of a computational skin model with varying levels of oxygen saturation.
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