High-resolution high-speed chemical imaging through mid-infrared photothermal microscopy

Ji-Xin Cheng

doi:10.1117/12.2660667

6 March 2023 High-resolution high-speed chemical imaging through mid-infrared photothermal microscopy

Ji-Xin Cheng

Proceedings Volume PC12373, Optical Biopsy XXI: Toward Real-Time Spectroscopic Imaging and Diagnosis; PC1237304 (2023) https://doi.org/10.1117/12.2660667
Event: SPIE BiOS, 2023, San Francisco, California, United States

Abstract

Recently developed mid-infrared photothermal (MIP) microscopy (for a Review, Science Advances, 2021, 7: eabg1559) not only overcomes the diffraction limit in direct IR imaging, but also circumvents the limitations in AFM-IR. In MIP microscopy, a visible beam probes the thermal effects induced by an intensity-modulated infrared beam. The MIP signals are measured in scanner manner or in wide-field manner. Video rate MIP imaging of living cells and tissues has been reached through a single pulse digitization approach. In this presentation, I will discuss the principle, instrumentation, and applications of MIP microscopy.

Conference Presentation

Citation Download Citation

Ji-Xin Cheng "High-resolution high-speed chemical imaging through mid-infrared photothermal microscopy ", Proc. SPIE PC12373, Optical Biopsy XXI: Toward Real-Time Spectroscopic Imaging and Diagnosis, PC1237304 (6 March 2023); https://doi.org/10.1117/12.2660667

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