Alzheimer’s disease in the mouse eye: retinal characteristics of APPSL and 5xFAD models

Conrad W. Merkle; Antonia Lichtenegger; Jörg Neddens; Estibaliz Etxeberria; Stefanie Flunkert; Manuela Prokesch; Gerhard Garhöfer M.D.; Bernhard Baumann

doi:10.1117/12.3002543

13 March 2024 Alzheimer’s disease in the mouse eye: retinal characteristics of APPSL and 5xFAD models

Conrad W. Merkle, Antonia Lichtenegger, Jörg Neddens, Estibaliz Etxeberria, Stefanie Flunkert, Manuela Prokesch, Gerhard Garhöfer M.D., Bernhard Baumann

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Proceedings Volume PC12828, Neural Imaging and Sensing 2024; PC128280D (2024) https://doi.org/10.1117/12.3002543
Event: SPIE BiOS, 2024, San Francisco, California, United States

Abstract

Alzheimer’s Disease (AD) is a progressive neurodegenerative disease that severely impacts quality of life, so biomarkers that help identify AD are highly sought after. Here, we investigated the retinas of APPSL and 5xFAD mouse models and wild-type littermate controls, provided by QPS Austria GmbH, using a custom optical coherence tomography (OCT) ophthalmoscope. Features of interest including retinal thickness, the visibility of the photoreceptor inner and outer segment junction, and vessel density were quantified from the OCT images, with a number of significant differences between groups. This study identifies potential AD biomarkers and reemphasizes the importance of using proper age-matched controls.

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Conrad W. Merkle, Antonia Lichtenegger, Jörg Neddens, Estibaliz Etxeberria, Stefanie Flunkert, Manuela Prokesch, Gerhard Garhöfer M.D., and Bernhard Baumann "Alzheimer’s disease in the mouse eye: retinal characteristics of APPSL and 5xFAD models", Proc. SPIE PC12828, Neural Imaging and Sensing 2024, PC128280D (13 March 2024); https://doi.org/10.1117/12.3002543

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KEYWORDS

Alzheimer disease

Control systems

Eye

Eye models

Visibility

Animal model studies

Optical coherence tomography

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