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13 March 2024 Sub-macular scleral birefringence in children with myopia measured by triple-input polarization sensitive optical coherence tomography
Xinyu Liu, Parakkel R. Radhakrishnan, Jacqueline Chua, Quan V. Hoang, Audrey Chia, Marcus Ang, Seang-Mei Saw, Martin Villiger, Leopold Schmetterer
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Proceedings Volume PC12830, Optical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XXVIII; PC1283008 (2024) https://doi.org/10.1117/12.3005690
Event: SPIE BiOS, 2024, San Francisco, California, United States
Abstract
We report a pioneer clinical study using triple-input polarization-sensitive optical coherence tomography (TRIPS-OCT) to assess sub-macular scleral birefringence in 60 children with myopia. Results showed a significant difference in scleral birefringence between high and low myopia groups. In addition, we observed a correlation between axial length and birefringence in the low myopia group. This suggests the potential of using sub-macular scleral birefringence as a biomarker for myopia progression. Despite a high exclusion ratio due to inadequate scleral visibility and other limitations, these findings warrant further large-scale studies.
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Xinyu Liu, Parakkel R. Radhakrishnan, Jacqueline Chua, Quan V. Hoang, Audrey Chia, Marcus Ang, Seang-Mei Saw, Martin Villiger, and Leopold Schmetterer "Sub-macular scleral birefringence in children with myopia measured by triple-input polarization sensitive optical coherence tomography", Proc. SPIE PC12830, Optical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XXVIII, PC1283008 (13 March 2024); https://doi.org/10.1117/12.3005690
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KEYWORDS
Birefringence
Optical coherence tomography
Polarization
Design and modelling
Risk assessment
Statistical analysis
Visibility
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